GENOM Corporation is the primary manufacturer and distributor of the bio-organic constructs known as "Boomers". This makes GENOM the primary enemy of the Knight Sabers - led by Sylia Stingray, daughter of the man who created the Boomers. In both versions of the series, GENOM is run by a mysterious figure named Quincy, though the depiction of Quincy varies from one continuity to another (in the original series he was a dangerous, hands-on owner, while in Tokyo 2040 he is almost a puppet vegetable of a man, so old and decrepit he needs tubes and wires to keep himself alive while insanely dreaming of a boomer/human paradise). Brian J. Mason also works for GENOM, and his schemes are either offshoots of or interference to Quincy's.

To show the power and domination of GENOM, the viewer is shown the gargantuan GENOM Towers, which stand in many of that world's most important cities. These towers bear a resemblance to the Tower of Babel, both in appearance and in symbolism, as well as the Tyrell Corporation's tower in Blade Runner.

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